- Atlanta Falcons safety Richie Grant suffered an ankle injury against the Buccaneers and did not return. Linebacker Adetokunbo Ogundeji also suffered an ankle injury.
- Baltimore Ravens offensive tackle Patrick Mekari injured his hand against the Steelers. John Harbaugh said after the game that cornerback Marlon Humphrey is set to undergo an MRI for an unspecified injury, adding that it "could be a while" before he returns to the lineup. NFL Network Insider Ian Rapoport reported Humphrey is suspected to have suffered a season-ending shoulder injury.
- Cincinnati Bengals linebackers Markus Bailey (shoulder) and Logan Wilson (shoulder) were ruled out against the Chargers. Cornerback Chidobe Awuzie suffered a foot injury.
- The Houston Texans announced quarterback Tyrod Taylor was evaluated for injury and cleared to play but was replaced by rookie Davis Mills against the Colts.
- Jacksonville Jaguars offensive lineman Brandon Linder (back) and cornerback Tyson Campbell (abdominal) exited early against the Rams.
- Las Vegas Raiders running back Kenyan Drake suffered a broken ankle on Sunday is out for the season, Rapoport reported. In his first season with Las Vegas, Drake was the team's second-leading rusher. Linebacker Nick Kwiatkoski (ankle) was also ruled out. Linebacker Denzel Perryman (ankle) exited early.
- Los Angeles Chargers defensive end Joey Bosa was ruled out after exiting in the first half against the Bengals to be evaluated for a head injury.
- Miami Dolphins running back Patrick Laird suffered a knee injury against the Giants and was ruled out.
- Minnesota Vikings wideout Adam Thielen was ruled out against the Lions with an ankle injury that NFL Network's Tom Pelissero reports is a high ankle sprain. Pelissero added Thielen will undergo further testing to determine the severity.
- The New England Patriots announced linebacker Ronnie Perkins (illness) has been downgraded to out for Monday's game against the Bills.
- New York Giants quarterback Mike Glennon sustained a concussion against the Dolphins. Glennon started in place of Daniel Jones, who did not play due to a neck injury.
- New York Jets cornerback Michael Carter was evaluated for a concussion. Guard Laurent Duvernay-Tardif (ankle) did not return against the Eagles. Tight end Ryan Griffin (ankle) and wideout Corey Davis (ankle) also did not return.
- Philadelphia Eagles linebacker Patrick Johnson (back) and cornerback Steven Nelson (shoulder) were ruled out against the Jets. Running back Miles Sanders (ankle) was also ruled out.
- San Francisco 49ers running back Trenton Cannon was taken off the field in an ambulance after sustaining a concussion on the opening kickoff against the Seahawks. Cannon was transported to a local hospital for further evaluation, per the game's broadcast. The Niners announced he is in stable condition and will stay at the hospital overnight. Cornerback Emmanuel Moseley (ankle) has also been ruled out. Safety Jaquiski Tartt injured his hamstring. Running back Elijah Mitchell was evaluated for a head injury.
- Seattle Seahawks guard Kyle Fuller suffered an ankle injury against the 49ers. Safety Jamal Adams (shoulder) was ruled out. Defensive tackle Bryan Mone (knee) did not return.
- Tampa Bay Buccaneers cornerback Jamel Dean was ruled out against the Falcons after being evaluated for a concussion. Running back Ronald Jones (illness) did not return.
- Washington Football Team tight end Logan Thomas is expected to be done for the season after likely sustaining a torn ACL, Rapoport reported. Thomas will have an MRI to confirm. Thomas was injured when Raiders defensive end Yannick Ngakoue dropped down to avoid a Thomas block and took out the tight end's leg. Linebacker Khaleke Hudson (ankle) exited early versus the Raiders.
NFL news roundup: Latest league updates from Tuesday, March 21
NFL.com keeps you up to date with all of the latest league news from around the NFL. Visit NFL.com's transaction hub for a daily breakdown.
Patriots linebacker, three-time Super Bowl champion Dont'a Hightower announces retirement
Former New England Patriots linebacker and three-time Super Bowl champion Dont'a Hightower announced on Tuesday that he is retiring from the NFL after nine seasons.
New Titans DE Arden Key 'felt disrespected' by former team, AFC South rival Jaguars
Tennessee Titans defensive end Arden Key said in his introductory presser that he "felt disrespected" by the Jaguars.
Packers' Mark Murphy addresses Aaron Rodgers situation: 'I'm sworn to secrecy not to say anything'
The last time Packers president Mark Murphy spoke about Aaron Rodgers, it fanned some flames. So this time around, the CEO is zippering his lips. Speaking Monday at the Wisconsin Tech Summit at Lambeau Field, Murphy joked when asked about the Rodgers situation.
Lions' C.J. Gardner-Johnson has 'no bad blood' with Eagles: 'You got to do what's best for your family'
The moment it was reported C.J. Gardner-Johnson signed a one-year deal with the Lions, the social media scuttle suggested something went awry with his negotiations with the Eagles. The DB addressed the fallout in his intro presser on Monday.
Austin Ekeler has 'great relationship' with Chargers but 'relentlessly pursuing' opportunity for better deal
After receiving permission to explore trade options, Los Angeles Chargers running back Austin Ekeler clarified that the request is only contract-based and has nothing to do with his relationship with the organization.
Former Panthers, Patriots QB Cam Newton announces he'll throw at Auburn on Tuesday
AP NFL 2015 Most Valuable Player Cam Newton, who hasn't played since the 2021 season, announced via social media on Monday his plans to throw at his alma mater Auburn's pro day on Tuesday.
Bills sign ex-Patriots RB Damien Harris after losing Devin Singletary
The Bills are signing former New England Patriots back Damien Harris, NFL Network Insider Ian Rapoport reported.
Browns bringing back ex-Titans QB Josh Dobbs on one-year deal
QB Joshua Dobbs is signing a one-year deal with the Browns to be Deshaun Watson's backup, his agent Mike McCartney announced Monday.
WR Brandin Cooks 'couldn't be more hungry' after trade to Cowboys
After waiting to be sent elsewhere for close to a calendar year (if not longer, depending on who you ask), former Texans wide receiver Brandin Cooks is happy to be in Dallas with the Cowboys, where he sees an opportunity to make an impact on a team that expects to win.
Texans signing ex-Cowboys TE Dalton Schultz, ex-Bills RB Devin Singletary
Houston is adding some firepower on offense. The Texans are signing former Cowboys tight end Dalton Schultz and former Bills running back Devin Singletary.
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