Injuries: Evan Engram (knee) ruled out vs. Eagles

With their season potentially on the line at this point, the 1-4 Giants will be without one of their exciting young playmakers.

Tight end Evan Engram (knee) has been ruled out for New York's Thursday night meeting with the Philadephia Eagles.

Engram hasn't played since the Giants' Week 3 win over the Houston Texans, but appeared to be on track to resume the success he experienced as a rookie. More like a wide receiver than a traditional tight end, the pass-catcher has 10 catches for 104 yards and one touchdown in roughly nine quarters of action this season.

On a positive note for the Giants, edge rusher Olivier Vernon (ankle) appears set to make his 2018 debut. Vernon missed the first five games of the season due to injury, but didn't appear on the team's injury report Wednesday.

Here are the other injuries we're monitoring Wednesday:

1. Jacksonville Jaguars coach Doug Marrone ruled out running backLeonard Fournette (hamstring) and cornerback D.J. Hayden (toe) from playing Sunday against the Dallas Cowboys. GuardAndrew Norwell is day to day with a left leg injury, NFL Network Insider Ian Rapoport reported.

2. Atlanta Falcons running back Devonta Freemandid not practice because of a foot injury.

3. Tennessee Titans offensive tackle Taylor Lewan (foot) and safety Kenny Vaccaro (elbow) each sat out practice.

4. Los Angeles Rams wide receivers Brandin Cooks and Cooper Kupp remain in concussion protocol, but coach Sean McVay said the team believes they should be "ready to go" against the Denver Broncos on Sunday, barring any setbacks. Both participated in the walkthrough portion of practice Wednesday. McVay said kicker Greg Zuerlein is "probably" another week away from returning from a groin injury.

5. Miami Dolphins offensive tackle Laremy Tunsil remains in concussion protocol and defensive end Andre Branch (knee) returned to practice.

6. The Philadelphia Eagles ruled out safety Corey Graham (hamstring), defensive tackle Haloti Ngata (calf) and running back Darren Sproles (hamstring) for Thursday's game against the Giants.

7. The Tampa Bay Buccaneers saw a couple of key youngsters practice Wednesday after missing at least part of Tampa Bay's last game, a Week 4 loss to Chicago. Tight end O.J. Howard (knee) and cornerback Carlton Davis (groin) participated in practice.

8. Carolina Panthers tight end Greg Olsen was limited in practice. It remains to be seen whether or not he'll make his return from a fractured foot this week against the Washington Redskins. Defensive tackle Kawann Short (ankle) did not practice.

9. Indianapolis Colts wide receiver T.Y. Hilton (hamstring) and tight endJack Doyle (hip) are week to week, coach Frank Reich said. Both players didn't practice Wednesday and they aren't expected to play against the New York Jets on Sunday. Wide receiver Malik Hooker (back) and rookie linebacker Darius Leonard (ankle) also didn't practice.

10. Cincinnati Bengals wide receiver John Ross was limited in practice with a groin injury. Defensive end Michael Johnson and cornerback William Jackson also were limited because of knee injuries. Running back Giovani Bernard (knee) sat out practice.

11. New York Jets running back Isaiah Crowell (ankle), defensive backsTrumaine Johnson (quad) and Buster Skrine (Concussion) and wide receiver Charone Peake (hamstring) all sat out practice. Wide receiver Terrelle Pryor (groin), defensive backMarcus Maye (ankle/foot) and tight end Neal Sterling (concussion) were limited.

12. Buffalo Bills safeties Rafael Bush (shoulder) and Micah Hyde (groin) were limited in practice, as was cornerback Tre'Davious White (ankle).

13. Houston Texans quarterbackDeshaun Watson (chest) and running back Lamar Miller (chest) were each limited in practice. Wide receivers DeAndre Hopkins (foot), Will Fuller (hamstring) and Keke Coutee (hamstring) were each limited in practice.

14. Kansas City Chiefs coach Andy Reid said it will be "a stretch" for linebacker Justin Houston (hamstring) to play Sunday against the New England Patriots. Reid said safety Eric Berry remains day to day with a heel injury.

15. Baltimore Ravens cornerback Brandon Carr (knee) didn't practice and linebacker Tim Williams (hamstring) was limited.

16. Multiple Arizona Cardinals veterans did not practice Wednesday: receiver Larry Fitzgerald (hamstring/back), safety Tre Boston (shoulder), tight end Jermaine Gresham (Achilles), offensive linemen D.J. Humphries (knee) and Mike Iupati (shoulder) and defensive tackle Robert Nkemdiche (foot).

17. Minnesota Vikings running back Dalvin Cook (hamstring) was limited in practice, while safety Andrew Sendejo (groin), tackle Riley Reiff (foot) and defensive end Tashawn Bower (ankle) did not practice.

18. Los Angeles Chargers wide receiver Travis Benjamin (foot), linebacker Jatavis Brown (groin) and linebacker Kyzir White (knee) did not practice Wednesday, while three offensive linemen -- Joe Barksdale (knee), Russell Okung (groin), Mike Pouncey (knee) -- were limited.