DETROIT -- The first priority was to get the ball back, and Detroit was in good position to do that on third-and-long.
The Lions trailed 23-10 before Stafford threw two scoring passes in the final 3:38 - with Quin's interception coming between them.
"Our defense did a great job of getting us the ball back," Stafford said. "We fight, we never gave up, obviously had to have some things go our way, made some plays and won the game."
Detroit caught another break when Rafael Bush was called for pass interference on fourth down. Stafford eventually connected with Fuller in the back of the end zone for a 5-yard touchdown and the win.
"I thought the penalties ended up hurting us," New Orleans coach Sean Payton said. "I wasn't happy with how that game was officiated. I'll leave it at that, and yet that wasn't the reason in the end."
Detroit won for the second straight week without star receiver Calvin Johnson, who is nursing an ankle problem. The Lions sputtered for most of the game before Tate caught Stafford's pass around his own 35, turned up the field and outran two New Orleans defenders who looked as if they had good angles to make the tackle.
Tate caught 10 passes for 154 yards, both career highs.
"That play he made on that long touchdown is as good of a play as I've seen in a long time," said Stafford, who has seen his share of impressive receiving plays in Detroit. "Gave him a chance on a ball. He came back and caught it, he did the rest."
"We knew on third down that Drew likes to go to the sticks, and he likes to throw in the middle of the field," Quin said. "The D-line was closing in on him, and he tried to look me off a little bit, but he was trying to hit the tight end or somebody coming right across the field. All the film study, all the preparation added up, and we were able to make a big play."
On fourth-and-5 from the 9, Stafford threw toward running back Reggie Bush, who had not been much of a factor against his former team. Bush appeared to be short of the first-down marker, and the ball fell incomplete - but Rafael Bush arrived a bit early, and the penalty gave the Lions a new set of downs.
Fuller made a nice jumping catch in the back of the end zone and got both feet down for the final touchdown.
Cornerback Darius Slay broke up a fourth-down pass by Brees with 21 seconds remaining to seal the win. During one stretch in the fourth quarter, Brees went 10 straight passes without a completion, the longest dry spell of his career, according to STATS.
"The worst feeling in professional sports is when you feel like you let your team down," Brees said. "That's the way I feel right now with that interception."
Brees did throw for 342 yards and two touchdowns, including a 46-yarder to Kenny Stills in the third quarter that put New Orleans ahead 17-3. Stafford threw for 299 yards and two touchdowns, although he threw a pair of interceptions that nearly cost Detroit dearly.
NOTES: New Orleans TE Jimmy Graham, who has been dealing with a shoulder injury, played but did not catch a pass. He was targeted only twice. ... Saints C Jonathan Goodwin left in the second quarter with a left leg injury. New Orleans also lost NT Brodrick Bunkley in the second half to a concussion, and fellow DL Glenn Foster left with a knee injury. ... Stafford tied Bobby Layne for Detroit's career lead with his 118th touchdown pass.
Copyright 2014 by The Associated Press