Throughout the 2022 NFL season, NFL Network analysts will provide one bold prediction heading into each week's slate of games (see the full Week 1 schedule).
Another year, another season of hope at the quarterback position for the Colts. However, the Matt Ryan era starts just as the team's 2021 season ended: with Indianapolis suffering the biggest upset of the weekend. In Week 18 of last season, it was a shocking loss in Jacksonville with a playoff bid on the line. This Sunday, the Colts fall in Houston, dropping Indy to 0-9 in Week 1 since 2014, per NFL Research. The Texans' second-year QB, Davis Mills, outplays the Colts' veteran signal-caller, while Houston rookie CB Derek Stingley Jr. justifies his lofty draft status with an interception in his first NFL game.
The Bengals went to work this offseason, overhauling their O-line after Joe Burrow was the most-sacked quarterback in the NFL in 2021. Replacing four of their five starters along the offensive front from Super Bowl LVI pays off big time, as the Steelers, who led the NFL in sacks a year ago, don't record a single one in their Week 1 trip to Cincy.
Full NFL Week 1 schedule
Sunday, September 11
- New Orleans Saints at Atlanta Falcons (1 p.m. ET on FOX)
- Cleveland Browns at Carolina Panthers (1 p.m. ET on CBS)
- San Francisco 49ers at Chicago Bears (1 p.m. ET on FOX)
- Pittsburgh Steelers at Cincinnati Bengals (1 p.m. ET on CBS)
- Philadelphia Eagles at Detroit Lions (1 p.m. ET on FOX)
- Indianapolis Colts at Houston Texans (1 p.m. ET on CBS)
- New England Patriots at Miami Dolphins (1 p.m. ET on CBS)
- Baltimore Ravens at New York Jets (1 p.m. ET on CBS)
- Jacksonville Jaguars at Washington Commanders (1 p.m. ET on FOX)
- New York Giants at Tennessee Titans (4:25 p.m. ET on FOX)
- Kansas City Chiefs at Arizona Cardinals (4:25 p.m. ET on CBS)
- Las Vegas Raiders at Los Angeles Chargers (4:25 p.m. ET on CBS)
- Green Bay Packers at Minnesota Vikings (4:25 p.m. ET on FOX)
- Tampa Bay Buccaneers at Dallas Cowboys (8:20 p.m. ET on NBC/Universo)
Monday, September 12
- Denver Broncos at Seattle Seahawks (8:15 p.m. ET on ESPN/ABC/ESPN2/ESPN Deportes)