Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 10 fantasy matchups.
Houston Texans at Jacksonville Jaguars: 1:00 p.m. ET on CBS
Lamar Miller, RB -- START: As long as the passing game sputters, Miller should continue to see a lot of work. A matchup against a middle-of-the-road defense should help him post nice numbers.
Will Fuller, WR -- SIT (OUT): Since Week 4, Fuller has a total of 49 receiving yards. And it took a 23-yard outburst in Week 8 just to get there. He's officially out in Week 10.
Blake Bortles, QB -- SIT: Waiting for a fourth-quarter explosion from an otherwise dysfunctional quarterback is no way to live.
T.J. Yeldon, RB -- SIT: Yeldon is averaging fewer than nine carries per game and has topped 40 rushing yards in a game just once this season. Why are you even considering this?
Chris Ivory, RB -- SIT: Ivory has been marginally better than Yeldon this season. That margin isn't big enough for him to earn a spot in your lineup.
Allen Robinson, WR -- FLEX: The frustration you feel about starting Robinson each week is only matched by Robinson's visible frustration on the field. A recent bump in production is encouraging, but he's still not the WR1 you thought you were drafting.
Allen Hurns, WR -- FLEX: There's an asterisk here as Hurns works through concussion protocol, but he's had his moments in an otherwise forgettable season.
Marqise Lee, WR -- FLEX: This is more of a longshot play as Lee's value is predicated on his ability to get yards after the catch. But hey, people have done crazier things in fantasy.
Denver Broncos at New Orleans Saints: 1:00 p.m. ET on CBS
Mark Ingram, RB -- SIT: Was last week a fluke or the start of something big? Considering the past, we're going with more of the former.
Michael Thomas, WR -- START: Thomas might not be the top fantasy receiver in New Orleans, but he's been more consistent and has earned a greater target share in the past three games.
Willie Snead, WR -- FLEX: Combining Thomas' consistency with Cooks' big play ability makes Snead like having your chocolate and peanut butter together.
Los Angeles Rams at New York Jets: 1:00 p.m. ET on FOX
Bryce Petty, QB -- SIT: Petty is making his first career NFL start. That's all well and good, but don't make this the week he also gets his first fantasy start.
Brandon Marshall, WR -- FLEX: It's hard to sit a player like Marshall, but he hasn't found the end zone in a month with a high yardage total of 70 in that span. He still leads the team in targets, though, so there's hope for a bounce-back, although Petty under center gives us extra pause.
Quincy Enunwa, WR -- SIT: Enunwa had a few nice games in a row, but those were bouyed by big plays. He's too much of a risk right now with Fitzpatrick playing so poorly.
Atlanta Falcons at Philadelphia Eagles: 1:00 p.m. ET on FOX
Carson Wentz, QB -- SIT: Wentz has posted fewer than 12 fantasy points in each his last four games. He's not a viable fantasy quarterback.
Ryan Mathews, RB -- FLEX: Mathews' snap count has been dangerously low the last few weeks, but he continues to get the valuable goal-line work. We don't see that changing this week, which makes him a solid flex play. Just tread with caution, because his fantasy value is dependent solely on scoring touchdowns.
Kansas City Chiefs at Carolina Panthers: 1:00 p.m. ET on CBS
Alex Smith, QB -- START: If you're in need of a streamer, Smith makes senses as a high-ceiling type of play. Of course, we know, even in a great spot that Smith doesn't have a tangible ceiling.
Spencer Ware, RB -- FLEX: Not many players have the locked-in workload of Ware, who returns to a feature back role after Charcandrick West did nothing to threaten his touches in a week where he started in place of a concussed Ware. The Panthers have allowed just 3.1 yards per carry to running backs over the last four weeks, so it's not a great spot, but you can't turn away from Ware here.
Chiefs WRs -- FLEX:Chris Conley, Albert Wilson and Tyreek Hill all deserve consideration against the Panthers this week with Jeremy Maclin likely to miss this contest. Wilson was the favorite target in Week 9, Conley is the most physically freakish and Hill has shown big-play ability in multiple game sthis year.
Jonathan Stewart, RB -- FLEX: The volume and scoring-area touches are always on the table for Stewart, but he showed you his rather ugly 15-carry 42-yard floor last week. The Chiefs do rank 18th in football Outsiders' run defense DVOA and allowed the Jaguars run game to get off the schneid last week.
Kelvin Benjamin, WR -- START: One trend that's held up, and gotten stronger throughout the season, is the Chiefs corners opposite Marcus Peters bleeding production to opposing wideouts. Benjamin lines up at left wide receiver on 51 percent of his snaps, which will put him in position to battle those inferior defensive backs.
Chicago Bears at Tampa Bay Buccaneers: 1:00 p.m. ET on FOX
Jay Cutler, QB -- START: Cutler is a top streaming option this week against one of the league's worst pass defenses. The Bucs have allowed 1,087 yards of total offense in their last two games and are surrendering 29 points per game to opposing teams.
Alshon Jeffery, WR -- START: For the same reasons that Cutler is a top streaming option this week, Jeffery has WR1 upside. The Bucs are awful against the pass and Jeffery should thrive in what could turn into a shootout.
Zach Miller, TE -- START: Miller will be a low-end TE1 option with Cutler under center against a soft Bucs pass defense.
Jameis Winston, QB -- START: Despite the Bucs' inability to win games lately, Winston has been playing well from a fantasy perspective with nine touchdown passes and just one interception in his last four games. He'll likely be throwing a ton to make up for Tampa Bay's defensive ineffectiveness.
Doug Martin, RB -- SIT: Martin returned to practice this week after sitting out for nearly two months with a hamstring injury. It sounds as if he'll play, but on a "limited" workload. We'd advise keeping him on the bench and following a cautious "wait and see" approach.
Minnesota Vikings at Washington Redskins: 1:00 p.m. ET on FOX
Sam Bradford, QB -- SIT: Washington isn't a fearsome defense, but there's just no tangible upside with Bradford right now behind a porous offensive line.
Vikings RBs -- SIT:: You can run on Washington, but this group has been a complete disaster all season and now they're splitting the work three ways.
Stefon Diggs, WR -- START: In a homecoming game for him, Diggs is in a solid spot against Washington. He should be able to avoid Josh Norman's shadow coverage as his slot snaps are on the rise. Averaging 47 percent for the season, Diggs has played 50 and 67 percent of his snaps in the slot over the last two weeks.
Kyle Rudolph, TE -- START: There aren't many tight ends that have a locked-in target share like Rudolph. Given his red-zone usage upside, he's too good to sit.
Kirk Cousins, QB -- START: It doesn't look like we need to all-out avoid the Vikings defense like we did early in the season, as they've allowed a 64.2 completion rate over the last two weeks. Washington can pick on teams in the middle of the field, and you can probably get away with playing Cousins.
Green Bay Packers at Tennessee Titans: 1:00 p.m. ET on FOX
Aaron Rodgers, QB -- START: Forget YPA, Rodgers is heating up in fantasy in recent weeks. He's a strong QB1 start this week against a suspect Tennessee secondary.
Packers WRs -- START: For the most part, we're starting all members of this passing attack until Green Bay finds a running game. Rodgers averages nearly 46 passes per game since Week 6. Jordy Nelson is a WR1, Davante Adams is a WR2, and Ty Mongtomery is a strong play at WR or in the flex, given his added rushing attempts. Randall Cobb looks to be cleared from his injury and scored a touchdown last week on minimal snaps. He'll be a strong start here.
Marcus Mariota, QB -- START: Mariota has thrown two-plus touchdowns in each of his last five games, with two rushing scores added in for good measure. He's a great start against an injured and unproven Green Bay secondary.
Miami Dolphins at San Diego Chargers: 4:05 p.m. ET on CBS
Jarvis Landry, WR -- FLEX: Head coach Adam Gase admitted the six targets Landry saw last week were not enough. He should bounce back this week, but with Ajayi rolling along Landry is seeing less looks (11.25 targets/game in first four games, 6.5 targets/game in last four), diminishing his fantasy value
Philip Rivers, QB -- START: Rivers and his speedy receivers should be able to find plenty of space to work against a Miami secondary giving up 7.25 yards per attempt.
Dontrelle Inman, WR -- START: Inman gets a big bump in this offense with Benjamin limited or even out. The former CFL star saw nine targets last week, tied for the team-high.
San Francisco 49ers at Arizona Cardinals: 4:25 p.m. ET on FOX
Colin Kaepernick, QB -- SIT: We assume you're astute enough to realize that last week's 22-point outburst has no bearing on what could come this week. If you're not, then let us help you. It doesn't.
Carlos Hyde, RB -- FLEX: We're still waiting to see if Hyde plays this week. If he does, the Niners have shown no fear in using him heavily in nearly any game script. The volume is encouraging.
Quinton Patton, WR -- SIT: Did you know Patton was San Francisco's leading receiver? Probably not. Does that change your opinion of whether he should start for your fantasy team? Probably not.
Carson Palmer, QB -- START: Palmer has underwhelmed this season, but few things can help a player "get right" like a date with the San Francisco defense.
David Johnson, RB -- START: The league's best running back against the league's worst run defense. This will be the easiest decision you'll make all week.
Larry Fitzgerald, WR -- START: Fitz has been scoring one for the old guys all season long and that's likely to continue again this week.
John Brown, WR -- FLEX: Brown has struggled with injuries and consistency this season, but there's always a chance for a big play against a wretched secondary.
J.J. Nelson, WR -- FLEX: Nelson is a deep sleeper after two touchdowns in Week 8. He has seen increased snaps lately but is still something of a boom-or-bust candidate.
Dallas Cowboys at Pittsburgh Steelers: 4:25 p.m. ET on FOX
Dak Prescott, QB -- START: Currently fantasy's QB9 for the season, Prescott's rookie season has been stellar from both a real-life and fantasy perspective. He's posted fewer than 18 fantasy points just twice all season and in his last two games he's racked up 27 and 23 points. You can safely start him against a Steelers' pass defense that has struggled.
Dez Bryant, WR -- START: Dez posted a measly 1.9 fantasy points last week sending his owners into a state of deep despair and unrest. He'll be fine and should still be started this week.
Jason Witten, TE -- START: With two touchdowns in his last two games, fantasy owners should ride Witten's hot streak.
Antonio Brown, RB -- START: Brown posted 85 yards and a touchdown last week after a very slow start. He's fantasy's fourth-highest scoring wideout this year and remains a no-brainer start every week.
Sammie Coates, WR -- SIT: Coates has just one catch in his last three games. He remains limited in practice with a finger injury and is not an ideal option at wideout this week given his recent struggles.
Seattle Seahawks at New England Patriots: 8:30 p.m. ET on NBC
Doug Baldwin, WR -- FLEX: Baldwin isn't as likely to hit a big play like he did last week, but the veteran receiver could see a solid floor if this game turns into an exchange of scoring.
Jimmy Graham, TE -- START: There's no way you can sit Graham right now, but keep in mind Bill Belichick often tries to limit the opposition's top threat. That's looking like Graham more and more every week.
Cincinnati Bengals at New York Giants: 8:30 p.m. ET on ESPN
Jeremy Hill, RB -- START: Hill finally earned back a respectable amount of playing time in Week 8, seeing 44 percent of the snaps after three straight weeks with 34 percent of fewer. He's running with confidence again, and is worth a start against a Giants defense allowing over four yards per carry in the last month.
Giovani Bernard, RB -- FLEX: Bernard has bounced back after a slow start to the season, averaging 11.58 fantasy points per game over the last month. He's a fine flex with an added boost in PPR formats.
A.J. Green, WR -- START: Green averages the second-most targets per game in the league. He cannot be benched in fantasy.
Giants RBs -- SIT: This backfield is in transition, with Rashad Jennings trying to hold onto the starting job while Paul Perkins sees more work. Last week, they split touches evenly (14 apiece) but couldn't produce, as Perkins "led the way" with 47 total yards. Neither back is worth starting at this point if you can help it.
Cleveland Browns at Baltimore Ravens: 8:25 p.m. on NFL Network (Thursday)
Cody Kessler, QB -- SIT: Even though Kessler is playing well in his last four games (four touchdowns, zero interceptions), he's not worth starting in fantasy.
Terrelle Pryor, WR -- FLEX: Pryor is sneakily a top-10 wide receiver on the year in both PPR and standard formats. He's tough to sit even in a bad spot.
Corey Coleman, WR -- FLEX: Coleman performed OK in his first game back, but we know his ceiling is worth chasing in fantasy thanks to his big-play ability.
Joe Flacco, QB -- START: Flacco has been a fantasy disaster this year, but is at home and favored to win against a defense that has allowed 22 passing touchdowns. He's also due for some positive touchdown regression, as noted on the "Living the Stream" podcast (around 20 minutes in). He's a solid streamer.