The Bills current backfield includes proven guys like LeSean McCoy, Frank Gore and T.J. Yeldon, but they also have Devin Singletary, Senorise Perry, Marcus Murphy and Christian Wade looking to stand out.

The Green Bay Packers placed their top rusher on injured reserve Tuesday after Aaron Jones suffered a knee injury in last Sunday's matchup vs. the Bears. That, and more injury updates happening around the NFL.

Detroit Lions linebacker Jarrad Davis lamented his costly penalty in Sunday's 14-13 loss to the Buffalo Bills. Davis said his "mental error" lost the game for his squad.

Miami Dolphins running back Frank Gore was among those to go down Sunday. Here are the injuries we're monitoring during Week 15 of the 2018 NFL season.

The Buffalo Bills' running back situation is in disarray for Sunday's home game against the Detroit Lions. That, and more injury updates around the NFL on game day.

LeSean McCoy exited Sunday's loss to the Jets in the first quarter with a hamstring injury. Per NFL Network Insider Ian Rapoport, McCoy is day-to-day with a hamstring strain.

The Dolphins pulled off a miracle in Miami and Patrick Mahomes was his usual magical self in the Chiefs' comeback win against the Ravens. Here's what else we learned from Sunday's Week 14 games.

LeSean McCoy's status, vital to a struggling Bills offense, remains uncertain ahead of Buffalo's Week 8 meeting with the New England Patriots. McCoy remains in the concussion protocol.

Missed Sunday's games? Around The NFL has you covered. Here's what we learned from the Week 7 matchups, including an AFC showdown in London.

Kansas City Chiefs wide receiver Sammy Watkins suffered a hamstring injury during the first quarter of Monday's game against the Denver Broncos and was ruled out.

Opportunity drives scoring in fantasy football. Alex Gelhar breaks down each team's volume from a fantasy perspective in his Week 4 Targets and Touches report!

Houston Texans coach Bill O'Brien blasted an East Texas school superintendent for his remarks about Deshaun Watson that were posted to an online news article after the team's loss Sunday.

The Buffalo Bills are not at full strength in the backfield ahead of Week 3's game against the Minnesota Vikings. LeSean McCoy was limited in practice dealing with injured ribs.

Week 2 of the NFL preseason is here, giving us the opportunity to reaffirm some of the standout performances we saw from high-profile rookies and unheralded grinders last week.

Buffalo Bills running back LeSean McCoy was carted off after suffering a sprained ankle on a carry during the third quarter of Sunday's game against the Miami Dolphins.

The Giants are 5-7, a bad record that is good enough for first place in the head-scratchingly inept NFC East. But that record doesn't tell the true story of a team that's been allergic to the big moment.

New Orleans Saints running back Khiry Robinson had surgery on a fractured tibia and his season is over, coach Sean Payton announced on Monday. Also, Trent Richardson worked out for the team.

The New England Patriots made a move Tuesday to bolster their depleted receiving corps, swinging a deal with the New Orleans Saints for wideout/returner Jalen Saunders.

C.J. Spiller has played all over the field for New Orleans in practice -- even returning kicks. The former Bills star has impressed his peers, leaving one Saints coach to gush over his "home run speed."

Minnesota Vikings fans will have to wait until the regular season to see Adrian Peterson. The running back is not expected to play during the preseason.

Sorting out the backfields of NFL rosters can be a difficult task. NFL Fantasy is here to help, with a complete breakdown of all 32 NFL backfields to help you prep for the fantasy football season.

As the rookies of 2015 settle in with their new teams, which ones will make the biggest immediate impact? Here's a ranking of the top 100, with Jameis Winston slotted at No. 1.

Buffalo Bills running back Marcus Murphy makes everybody miss on this spectacular punt return touchdown.

Watch complete highlights from the Week 10 matchup between the Buffalo Bills and the New York Jets.

Watch highlights from the Indianapolis Colts and Buffalo Bills, where the Indianapolis Colts defeat the Buffalo Bills at home for Week 7 of the 2018 season.

Buffalo Bills running back Marcus Murphy rushes for a 30-yard gain against the Indianapolis Colts for Week 7 of the 2018 season.

Buffalo Bills running back Marcus Murphy finds a hole in the line for a 18-yard gain against the Indianapolis Colts for Week 7.

Week 1 of the NFL season is off to the races. Here is a look at the best runs in the season openers.