The veteran wide receiver, who has been dealing with a hamstring injury, has been designated inactive by the club. Shepard briefly tested the hamstring in pregame, but didn't look ready to play, according to Dan Duggan of The Athletic. He had only limited participation in practice on Thursday and Friday and was listed as questionable to play.
His absence will make for an especially thin receiving corps for the Giants on Sunday. He will join Kenny Golladay and Kadarius Toney on the sideline, leaving quarterback Daniel Jones with a shortage of options around him in a struggling offense; Darius Slayton, a speedster who can provide a deep threat for the Giants, will lead a relatively inexperienced group. Saquon Barkley is out with an injury, as well.