An all-star offensive cast of Christian McCaffrey, Deebo Samuel and Brock Purdy all had contributions as their defense dominated en route to the 49ers defeating the Giants on Thursday night. 

NFL.com's Eric Edholm breaks down four things to watch for when the New York Giants visit the San Francisco 49ers on Thursday night.

The New York Giants have officially ruled out running back Saquon Barkley (ankle) for Thursday night's game against the San Francisco 49ers.

New York Giants head coach Brian Daboll wouldn't rule out the possibility on Tuesday that star running back Saquon Barkley actually could play Thursday night against the 49ers just days after hurting his ankle.

New York Giants RB Saquon Barkley suffered an ankle sprain that will keep him out of Thursday night's road game versus San Francisco and perhaps even longer, NFL Network Insider Ian Rapoport reported on Monday.

NFL.com keeps you up to date with all of the latest league news from around the NFL. Visit NFL.com's transaction hub for a daily breakdown.

The Giants' offense scored four second-half touchdowns, the defense shut Arizona out in the fourth quarter, and Graham Gano connected on a 34-yard FG with 19 seconds remaining for a miraculous 31-28 comeback win.

Here are the injuries and news we're monitoring around the league on this Week 2 Sunday.

Can Josh Jacobs win his second consecutive rushing title? Or will the ever-consistent Nick Chubb finally stake his claim to the throne? Just prior to Week 1 kicking off, Maurice Jones-Drew predicts 2023's top 10 leading rushers.

David Carr reveals his top 15 offensive player rankings -- a list that includes four teams with two players apiece -- heading into Week 1 of the 2023 NFL season. 

Despite not being able to agree on a long-term deal with the New York Giants this offseason, running back Saquon Barkley still wants to be with the team for the rest of his career.

Maurice Jones-Drew ranks all 32 RB1s heading into the 2023 NFL season. Is Saquon Barkley too low after a major bounce-back campaign? And who earns the No. 1 spot? Check out MJD's full pecking order.

Which elite NFL players are heading into a contract season? Gregg Rosenthal provides a way-too-early look at the top 50 free agents in 2024. While these rankings will look completely different by next March, they currently include 10 wide receivers.

It's that time of year again, when NFL players cast their votes to identify the best in the league heading into the 2023 NFL season. Which players joined Saquon Barkley and Christian McCaffrey from Nos. 40-31?

The 2023 NFL fantasy football season is here! Fantasy guru Adam Rank is here to help you prepare for your drafts by revealing his running back rankings and tiers.

Giants running back Saquon Barkley surprised many this week when he inked a one-year contract to report to training camp. On Thursday, Barkley opened up about his decision, explaining his reasoning.

"The Top 100 Players of 2023" is underway on NFL+, and FIVE running backs are among the selections that will be revealed in Nos. 40-21. With that in mind, David Carr provides his own ranking of the top 10 RBs.

The Giants and running back Saquon Barkley have agreed to terms on a one-year deal worth up to $11 million, NFL Network Insider Ian Rapoport reported, per sources.

As the debate rages on about whether teams should be willing to pay top-of-market prices for running backs, Bucky Brooks reveals a list of 10 RBs that he views as the engine of their respective offenses.

In an interview recorded prior to this week's franchise-tag deadline, New York Giants RB Saquon Barkley discussed his contract situation and the possibility of missing games this season.

Colts running back Jonathan Taylor and Titans runner Derrick Henry were a few of many RBs that took notice of the lack of multi-year deals at Monday's franchise tag deadline.

NFL.com keeps you up to date with all of the latest league news from around the NFL. Visit NFL.com's transaction hub for a daily breakdown.

Saquon Barkley's future in New York remains cloudy after sides couldn't agree on a long-term contract by Monday's deadline, NFL Network Insiders Ian Rapoport, Tom Pelissero and Mike Garafolo reported.

NFL Network Insider Mike Garafolo reported Giants running back Saquon Barkley, who had the franchise tag applied to him in March, understands the running back marketplace and is not looking for a market-setting deal. Garafolo added, however, that Barkley and the Giants are no closer on a deal. 

Will the Honey Badger lead the Saints back to the playoffs? How will A.J. Brown build on a sensational first year with the Eagles? Eric Edholm picks the top non-QB MVP candidate for each NFC team heading into the 2023 NFL season.

Prime Video 'TNF' analytics expert Sam Schwartzstein previews the New York Giants-San Francisco 49ers game.

Watch the win probabilities fluctuate drastically in the New York Giants comeback win over the Arizona Cardinals in Week 2 of the 2023 NFL season, according to Next Gen Stats.

Exploring New York Giants' offensive play-calling sans running back Saquon Barkley on 'The Insiders'.

The Insiders examines New York Giants running back Saquon Barkley's chances of playing vs. the San Francisco 49ers on "Thursday Night Football".

"GMFB discuss the New York Giants and the San Francisco 49ers ahead of their Week 3 matchup.

NFL Network's Ian Rapoport: New York Giants running back Saquon Barkley is week-to-week after ankle sprain vs. Arizona Cardinals.

NFL Network's Cynthia Frelund, Patrick Claybon and Adam Rank reveal what the fantasy football future holds for the New York Giants after RB Saquon Barkley's injury diagnosis.

NFL Network Insider Ian Rapoport is reporting New York Giants running back Saquon Barkley to undergo more tests on Monday on his ankle after leaving game during fourth quarter.

New York Giants running back Saquon Barkley slams helmet to ground on sideline after sustaining injury after being twisted up on a tackle on a short run late in the fourth quarter and being helped off the field.

New York Giants running back Saquon Barkley's pylon-reach TD pulls Giants within one score as he stretches fully out to reach the end zone on a 9-yard toss from quarterback Daniel Jones.

New York Giants running back Saquon Barkley's first TD of 2023 comes on third-and-goal in Week 2 as the Giants power into the end zone.

In a segment on 'NFL Fantasy Live', NFL Network's Adam Rank, Cynthia Frelund, Marcas Grant and Patrick Claybon predict who will be the top-scoring fantasy football running backs for Week 2 of the 2023 NFL regular season.

"NFL Fantasy Live" discusses New York Jets running back Saquon Barkley.

New York Giants running back Saquon Barkley accelerates through the hole for an 18-yard pickup.

The breakfast table performs their first Angry Runs draft ahead of the 2023 season.

NFL Network's David Carr: New York Giants tight end Darren Waller's presence will boost running back Saquon Barkley's effectiveness.

Splitting up RBs by scoring tiers | 'NFL Fantasy Live'

NFL Network's Patrick Claybon, Marcas Grant and Michael F. Florio go through a simulation of how the second round of your fantasy football draft could unfold in 2023.

NFL Network Insider Mike Garafolo on the New York Giants expectations for quarterback Daniel Jones entering 2023.

Former NFL linebacker Jonathan Casillas wakes up with "GMFB" and discusses how New York Giants running back Saquon Barkley handled contract negotiations, most surprising thing he heard from head coach Sean Payton.

NFL Network's LaDainian Tomlinson: I expect bigger receiving numbers from New York Giants running back Saquon Barkley in 2023.

NFL Network Insider Mike Garafolo says "the storyline has changed" with the New York Giants and running back Saquon Barkley agreeing to one-year deal ahead of training camp.

NFL Network insider Ian Rapoport reports on the details of New York Giants running back Saquon Barkley's new 1-year contract with the team.

NFL Network's Will Selva reports the details surrounding New York Giants running back Saquon Barkley and the adjusted franchise tag he just signed that is worth up to $11 million.

Senior National Columnist Judy Battista on the New York Giants and running back Saquon Barkley agreeing to one-year deal.