Kittle is dealing with a groin injury and didn't practice this week. In a long season, pushing it early doesn't make sense.
The Iowa product, selected to three Pro Bowls, had 71 receptions and six touchdown catches last season.
Trey Lance gets his third career start for the 49ers as they travel to Soldier Field to face the Bears. In two starts last season, Lance went 1-1.
Other injuries we are keeping an eye on ahead of Sunday's Week 1 games:
- Arizona Cardinals tight end Zach Ertz (calf) is likely to play at home against the Chiefs, assuming no issues warming up. However, defensive end J.J. Watt (calf) is not expected to play, according to Rapoport.
- Atlanta Falcons first-round rookie wide receiver Drake London, who has been nursing a minor knee injury, is active versus the Saints.
- Baltimore Ravens running back J.K. Dobbins (knee) will be inactive versus the Jets, NFL Network Insider Mike Garafolo reports. The team has since announced the news. Dobbins, who has yet to log a full practice, said he wants to play but the team his holding him back, per Garafolo.
- Detroit Lions center Frank Ragnow (groin) is officially active versus Philadelphia.
- The Green Bay Packers are expected to be without left tackle David Bakhtiari (knee), right tackle Elgton Jenkins (pectoral/knee) and wide receiver Allen Lazard (ankle) against the Minnesota Vikings, sources tell Rapoport and NFL Network Insider Tom Pelissero. Yosh Nijman is slated to start in Bakhtiari's place on Aaron Rodgers' blind side.
- Miami Dolphins defensive tackle Raekwon Davis (knee; questionable) should be a go today against the Patriots after suffering a mid-week injury, NFL Network's Cameron Wolfe reports. Davis has since been declared active versus New England while safety Eric Rowe (pectoral) is inactive.
- The Minnesota Vikings' first-round draft pick, safety Lewis Cine, won't play in today's opener against the Packers because of the knee issue he aggravated this week, per source. It's nothing major for Cine -- he just missed too much practice. Expect him to make his debut Week 2, according to Pelissero.
- New England Patriots wide receiver Jakobi Meyers, listed as questionable with a knee injury, is active versus the Dolphins. Offensive tackle Isaiah Wynn (back) is also active.
- New Orleans Saints wide receiver Michael Thomas (hamstring) is officially active and will play against the Falcons. It's the first time he'll be on the field since missing all of last season.
- Tampa Bay Buccaneers wide receiver Chris Godwin is expected to make his return from a torn ACL against the Cowboys in Dallas tonight, barring no setbacks in warmups. He may be eased back, but he should play, a source tells Rapoport.
- Washington Commanders tight end Logan Thomas, attempting to return from a torn ACL late last season, is active versus the Jacksonville Jaguars.