The Jaguars' offense will be without one of its brightest stars for the foreseeable future.
"Tough one. I don't know the extent. I heard it's a broken ankle," Jaguars head coach Urban Meyer said after the game. "And he was starting to play well. That's a big one."
Chark, 25, was carted off following the conclusion of the third play of the game's opening drive. He was injured after teammate James Robinson rolled on top of his leg while being tackled as the wideout attempted to set a block downfield.
With Chark out of the lineup, Trevor Lawrence will now look to generate offense with Marvin Jones, the team's leading receiver entering Week 4, second-year talent Laviska Shenault Jr. and newcomer tight end Dan Arnold.
Chark has accumulated seven receptions for 154 yards and two touchdowns in three starts this season.