Head coach Mike Tomlin's only update after the game was that Pickett needed to be evaluated.
Pickett sustained the injury on a fourth-down sack by Texans defensive end Jonathan Greenard at the tail end of the third quarter. Pickett required help to the sideline and was quickly ruled out by the team.
Mitchell Trubisky took over at QB with the Steelers trailing, 23-6.
Pickett was 15-of-23 passing for 114 yards and an interception before exiting the game.