Brock Purdy's best plays from 5-TD game vs. Colts | Week 16

Watch the best plays from San Francisco 49ers quarterback Brock Purdy's 5-touchdown game vs. the Indianapolis Colts in Week 16 of the 2025 NFL season.

Watch the best plays from San Francisco 49ers running back Christian McCaffrey's 146-yard game against the Indianapolis Colts in Week 16 of the 2025 NFL season.

Watch the best plays from San Francisco 49ers tight end George Kittle's 115-yard game vs. the Indianapolis Colts in Week 16 of the 2025 NFL season.

Watch the best plays from Indianapolis Colts quarterback Philip Rivers' 277-yard, two-touchdown game against the San Francisco 49ers in Week 16 of the 2025 NFL season.

Watch the best plays from New England Patriots wide receiver Stefon Diggs' 138-yard game against the Baltimore Ravens in Week 16 of the 2025 NFL season.

Watch the best plays from New England Patriots quarterback Drake Maye's 380-yard game against the Baltimore Ravens in Week 16 of the 2025 NFL season.

Watch the best plays from Baltimore Ravens running back Derrick Henry's 128-yard game against the New England Patriots in Week 16 of the 2025 NFL season.

Watch the best plays from Pittsburgh Steelers running back Kenneth Gainwell's 128-yard game against the Detroit Lions from Week 16 of the 2025 NFL season.

Watch the best plays from Pittsburgh Steelers running back Jaylen Warrens' 151-yard, 2-touchdown game against the Detroit Lions from Week 16 of the 2025 NFL season.

Watch the best plays from Detroit Lions quarterback Jared Goff's 364-yard, 3-touchdown game against the Pittsburgh Steelers from Week 16 of the 2025 NFL season.

Watching the best plays from Denver Broncos running back RJ Harvey 121-yard game against the Jacksonville Jaguars in Week 16 of the 2025 NFL season.

Watch the best plays from Denver Broncos quarterback Bo Nix's 352-yard game against the Jacksonville Jaguars during Week 16 of the 2025 NFL season.

Watch the best plays from Jacksonville Jaguars quarterback Trevor Lawrence's four-touchdown game against the Denver Broncos during Week 16 of the 2025 NFL season.

Las Vegas Raiders running back Ashton Jeanty totaled 188 yards with a pair of touchdowns in Week 16 against the Houston Texans.

Watch the best plays from Jacksonville Jaguars wide receiver Parker Washington's 145-yard game against the Denver Broncos in Week 16 of the 2025 NFL season.

Highlights of Atlanta Falcons running back Bijan Robinson during Week 16 of the 2025 NFL season where he had 92 receiving yards from 7 catches along with 76 rushing yards off 16 attempts against the Arizona Falcons.

Tennessee Titans running back Tony Pollard hit the century mark with a 102-yard rushing performance in Week 16 against the Kansas City Chiefs.

Tennessee Titans quarterback Cam Ward threw a pair of touchdown passes in his team's 26-9 win over the Kansas City Chiefs in Week 16.

Highlights of Minnesota Vikings wide receiver Justin Jefferson during Week 16 of the 2025 NFL season against the New York Giants.

Watch every catch from Dallas Cowboys wide receiver George Pickens' 130-yard game against the Los Angeles Chargers from Week 16 of the 2025 NFL season.

Watch every catch from Los Angeles Chargers wide receiver Quentin Johnston's 104-yard game against the Dallas Cowboys from Week 16 of the 2025 NFL season.

Watch the best plays from Los Angeles Chargers quarterback Justin Herbert from his 3-touchdown game against the Dallas Cowboys from Week 16 of the 2025 NFL season.

Highlights of Buffalo Bills running back James Cook during Week 16 of the 2025 NFL season where he had 16 carries for 117 yards on the ground another another 17 through the air to go with the 2 touchdowns he scored against the Cleveland Browns.

Watch Carolina Panthers quarterback Bryce Young's best plays from his 2-touchdown game vs. the Tampa Bay Buccaneers in Week 16 of the 2025 NFL season.

Cincinnati Bengals wide receiver Ja'Marr Chase's best catches from his 109-yard game vs. the Miami Dolphins during Week 16 of the 2025 NFL season.