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Bryce Young's play-action pass is picked off by Ji'Ayir Brown in the end zone

Carolina Panthers quarterback Bryce Young's play-action pass is intercepted in the end zone by San Francisco 49ers safety Ji'Ayir Brown for a massive turnover.

Top catches | Week 12

Watch the top catches from Week 12 of the 2025 NFL season.

Top touchdowns | Week 12

Watch the top touchdowns from Week 12 of the 2025 NFL season.

Top plays | Week 12

Watch the top plays from Week 12 of the 2025 NFL season.

Top defensive plays | Week 12

Watch the top defensive plays from Week 12 of the 2025 NFL season.

Top runs | Week 12

Watch the top runs from Week 12 of the 2025 NFL season.

Panthers vs. 49ers highlights | Week 12

Highlights from the Week 12 matchup between the Carolina Panthers and the San Francisco 49ers during the 2025 NFL season.

Christian McCaffrey's best plays from 142-yard game vs. Panthers | Week 12

Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers in Week 12 of the 2025 NFL season.

Ji'Ayir Brown snags his second INT of night on Bryce Young

Carolina Panthers quarterback Bryce Young's pass to wide receiver Tetairoa McMillan is intercepted by San Francisco 49ers safety Ji'Ayir Brown for the second time tonight.

Bryce Young zips RPO strike to Coker for 18 yards

Carolina Panthers quarterback Bryce Young executes the RPO to perfection as he hits wide receiver Jalen Coker over the middle for a 18-yard gain into San Francisco 49ers territory.

Matt Gay's 29-yard FG extends 49ers lead to 20-9

San Francisco 49ers kicker Matt Gay connects on a 29-yard field goal to extend the 49ers lead over the Carolina Panthers to 20-9.

Purdy's play-action pass goes to Kittle for a 19-yard catch and run

San Francisco 49ers quarterback Brock Purdy's play-action pass finds the wide open tight end George Kittle for a 19-yard catch and run against the Carolina Panthers.

Christian McCaffrey explodes upfield for 17-yard run into Panthers territory

San Francisco 49ers running back Christian McCaffrey bursts upfield for a 17-yard run into Carolina Panthers territory.

Bryce Young drops 29-yard TD pass in the bucket to Tetairoa McMillan

Carolina Panthers quarterback Bryce Young drops 29-yard touchdown dime to wide receiver Tetairoa McMillan to trim the San Francisco 49ers lead to 17-9.

Chuba Hubbard shows off nifty juke moves on 14-yard catch and run

Carolina Panthers quarterback Bryce Young hits running back Chuba Hubbard out of the backfield for a 14-yard catch and run after an electrifying juke move on a San Francisco 49ers defender.

Christian McCaffrey's TD run marks the first time he's ever scored against Panthers

San Francisco 49ers running back Christian McCaffrey takes the toss and bursts into the end zone for a 12-yard touchdown run against his former team.

3rd and Jauan! Jennings makes multiple defenders miss on 10-yard catch and run

San Francisco 49ers quarterbacks hits wide receiver Jauan Jennings for a 10-yard catch and run on third down into the red zone.

Rico Dowdle's spinning rush yields 17-yard pickup early in second half

Carolina Panthers running back Rico Dowdle makes multiple San Francisco 49ers defenders miss on an incredible spin move that results in a 17-yard run.

Matt Gay converts his first FG as a 49er

San Francisco 49ers kicker Matt Gay connects on a 47-yard field goal to extend the 49ers lead to 10-3 over the Carolina Panthers.

Purdy rips 25-yard strike to George Kittle

San Francisco 49ers quarterback Brock Purdy connects with tight end George Kittle over the middle for a 25-yard gain into Carolina Panthers territory.

Ryan Fitzgerald converts on 25-yard FG to trim 49ers lead to 7-3

Carolina Panthers kicker Ryan Fitzgerald connects on a 25-yard field goal to trim the San Francisco 49ers lead to 7-3.

Jaycee Horn undercuts Brock Purdy's pass for second INT of night

Carolina Panthers cornerback Jaycee Horn jumps the route and intercepts San Francisco 49ers quarterback Brock Purdy for the second time tonight.

McCaffrey's fumble is somehow recovered by 49ers after Carolina fails to jump on ball

San Francisco 49ers running Christian McCaffrey puts the ball on the ground but offensive tackle Colton McKivitz is somehow able to recover the fumble after multiple Carolina Panthers defenders are unable to recover it.

Can't-Miss Play: Mike Jackson leaps WAY upstairs for end-zone INT vs. Purdy

Carolina Panthers cornerback Mike Jackson leaps up and snatches an incredible interception in the end zone off San Francisco 49ers quarterback Brock Purdy.

Brock Purdy swiftly evades pressure on 9-yard run

San Francisco 49ers quarterback Brock Purdy eludes multiple Carolina Panthers defenders and runs for a 9-yard first down.

Christian McCaffrey's wicked juke move sparks 9-yard catch and run

San Francisco 49ers running back Christian McCaffrey makes a Carolina Panthers defender miss on a wicked juke move on a 9-yard pass from quarterback Brock Purdy.