Christian McCaffrey's TD run marks the first time he's ever scored against Panthers

San Francisco 49ers running back Christian McCaffrey takes the toss and bursts into the end zone for a 12-yard touchdown run against his former team.

Watch the top catches from Week 12 of the 2025 NFL season.

Watch the top touchdowns from Week 12 of the 2025 NFL season.

Watch the top plays from Week 12 of the 2025 NFL season.

Watch the top defensive plays from Week 12 of the 2025 NFL season.

Watch the top runs from Week 12 of the 2025 NFL season.

Highlights from the Week 12 matchup between the Carolina Panthers and the San Francisco 49ers during the 2025 NFL season.

Watch the best plays from San Francisco 49ers running back Christian McCaffery's 142-yard game against the Carolina Panthers in Week 12 of the 2025 NFL season.

Carolina Panthers quarterback Bryce Young's pass to wide receiver Tetairoa McMillan is intercepted by San Francisco 49ers safety Ji'Ayir Brown for the second time tonight.

Carolina Panthers quarterback Bryce Young executes the RPO to perfection as he hits wide receiver Jalen Coker over the middle for a 18-yard gain into San Francisco 49ers territory.

San Francisco 49ers kicker Matt Gay connects on a 29-yard field goal to extend the 49ers lead over the Carolina Panthers to 20-9.

San Francisco 49ers quarterback Brock Purdy's play-action pass finds the wide open tight end George Kittle for a 19-yard catch and run against the Carolina Panthers.

San Francisco 49ers running back Christian McCaffrey bursts upfield for a 17-yard run into Carolina Panthers territory.

Carolina Panthers quarterback Bryce Young drops 29-yard touchdown dime to wide receiver Tetairoa McMillan to trim the San Francisco 49ers lead to 17-9.

Carolina Panthers quarterback Bryce Young hits running back Chuba Hubbard out of the backfield for a 14-yard catch and run after an electrifying juke move on a San Francisco 49ers defender.

San Francisco 49ers quarterbacks hits wide receiver Jauan Jennings for a 10-yard catch and run on third down into the red zone.

Carolina Panthers running back Rico Dowdle makes multiple San Francisco 49ers defenders miss on an incredible spin move that results in a 17-yard run.

San Francisco 49ers kicker Matt Gay connects on a 47-yard field goal to extend the 49ers lead to 10-3 over the Carolina Panthers.

San Francisco 49ers quarterback Brock Purdy connects with tight end George Kittle over the middle for a 25-yard gain into Carolina Panthers territory.

Carolina Panthers kicker Ryan Fitzgerald connects on a 25-yard field goal to trim the San Francisco 49ers lead to 7-3.

Carolina Panthers cornerback Jaycee Horn jumps the route and intercepts San Francisco 49ers quarterback Brock Purdy for the second time tonight.

San Francisco 49ers running Christian McCaffrey puts the ball on the ground but offensive tackle Colton McKivitz is somehow able to recover the fumble after multiple Carolina Panthers defenders are unable to recover it.

Carolina Panthers cornerback Mike Jackson leaps up and snatches an incredible interception in the end zone off San Francisco 49ers quarterback Brock Purdy.

San Francisco 49ers quarterback Brock Purdy eludes multiple Carolina Panthers defenders and runs for a 9-yard first down.

San Francisco 49ers running back Christian McCaffrey makes a Carolina Panthers defender miss on a wicked juke move on a 9-yard pass from quarterback Brock Purdy.