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(NOTE: Teams listed in alphabetical order.)
- RB David Montgomery (thigh) is doubtful for Sunday's game versus the Falcons.
- WR Josh Reynolds (groin) questionable
- WR Amon-Ra St. Brown (toe) questionable
- OT Taylor Decker (ankle) ruled out
- OG Halapoulivaati Vaitai (knee) ruled out
- CB Emmanuel Moseley (knee/hamstring) ruled out
- S Kerby Joseph (hip) ruled out
- RB Salvon Ahmed (groin) is doubtful for Sunday's game versus the Broncos.
- WR Jaylen Waddle (concussion) is questionable. Head coach Mike McDaniel said that as of Friday, Waddle remains in the concussion protocol.
- LT Terron Armstead (back/ankle/knee) questionable
- DT Raekwon Davis (wrist) questionable
- LB Jaelan Phillips (back) questionable
- QB Will Grier officially signed to active roster from Bengals practice squad.
- QB Aaron Rodgers, who is out for the season with an Achilles tear, will hopefully be back in the building sometime next week, head coach Robert Saleh said.
- OL Duane Brown (shoulder/hip) is questionable, but Saleh said he feels good about Brown's availability for Sunday versus the Patriots.
- OL Wes Schweitzer (concussion) ruled out.
- DE John Franklin-Myers (hip) questionable
- S Tony Adams (hamstring) ruled out
- K Greg Zuerlein (right groin) questionable
- RB Kenneth Gainwell (ribs) was a full participant at practice.
- RB Boston Scott (concussion) limited
- WR DeVonta Smith (hamstring, thigh) limited
- WR Quez Watkins (hamstring) DNP
- DE Josh Sweat (toe) limited
- DT Fletcher Cox (ribs) full
- DT Jordan Davis (ankle) limited
- CB James Bradberry (concussion) full
- S Reed Blankenship (ribs) full
- S Terrell Edmunds (illness) DNP
- WR Gunner Olszewski (concussion) ruled out for Sunday's game versus the Raiders.
COACHING/FRONT OFFICE NEWS
- Head coach Kyle Shanahan and general manager John Lynch have signed multi-year extensions, the team announced Friday.
- CB Anthony Brown re-signed on a one-year deal
- WR Deebo Samuel had his injured ribs checked out from Thursday's win over the Giants and tests did not reveal a break, but he is "pretty sore" and is considered day to day, per head coach Kyle Shanahan.
- LB Dre Greenlaw is day to day with a low ankle sprain, per Shanahan.
- CB Tre Swilling
- WR DeAndre Hopkins (ankle) is questionable for Sunday's game versus the Browns.
- WR Kearis Jackson placed on injured reserve
- OG Peter Skoronski (illness) ruled out
- DE Denico Autry (foot) questionable
- S Amani Hooker has cleared concussion protocol, head coach Mike Vrabel told reporters.
- WR Mason Kinsey signed to active roster from the practice squad
- LB Chance Campbell signed to active roster from the practice squad
- LB Otis Reese